Ovulation Induction

 

 

Clomiphene citrate acts as an anti-estrogen which increases endogenous FSH and thereby stimulates multiple follicular developments [Ref]. While its effectiveness has been described in cases of oligo-ovulation, questions have been raised regarding its usefulness in otherwise ovulatory women with unexplained infertility [Ref]. A Cochrane review summarised 14 clinical trials (1159 participants), and found no clinical benefit of clomiphene citrate in unexplained subfertility [Ref].